Sulfanilic acid
Sulfanilic acid
CAS: 121-57-3
Molecular Formula: C6H7NO3S
Sulfanilic acid - Names and Identifiers
| Name | Sulfanilic acid |
| Synonyms | Sulfanilic acid Sulphanilic acid Sulphanillic Acid 4-Anilinesulfonic acid 4-aminobenzenesulfonate p-Aminobenesulfonic acid Mesalazine EP Impurity O SULFANILIC ACID ANHYD PWD 4-Aminobenzenesulfonic acid 4-Aminobenzenesulphonic acid BES SODIUM SALT HIGH PURITY GRADE Diazobenzenesulfonic acid test solution(ChP) SULFANILIC ACID, ANHYDROUS, REAGENT (ACS)SULFANILIC ACID, ANHYDROUS, REAGENT (ACS)SULFANILIC ACID, ANHYDROUS, REAGENT (ACS)SULFANILIC ACID, ANHYDROUS, REAGENT (ACS) |
| CAS | 121-57-3 |
| EINECS | 204-482-5 |
| InChI | InChI=1/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10)/p-1 |
| InChIKey | HVBSAKJJOYLTQU-UHFFFAOYSA-N |
Sulfanilic acid - Physico-chemical Properties
| Molecular Formula | C6H7NO3S |
| Molar Mass | 173.19 |
| Density | 1.485 |
| Melting Point | >300°C(lit.) |
| Boling Point | 288 ℃ |
| Water Solubility | 0.1 g/100 mL (20 ºC) |
| Solubility | 10g/l |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | solid |
| Color | White to Off-White |
| Merck | 14,8926 |
| BRN | 908765 |
| pKa | 3.24(at 25℃) |
| PH | 2.5 (10g/l, H2O, 20℃) |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 1.5500 (estimate) |
| Physical and Chemical Properties | Density 1.485 melting point 288°C (dec) water-soluble 0.1g/100 mL (20°C) |
| Use | Used in the manufacture of azo dyes, etc., also used as a pesticide for the prevention and control of wheat rust |
Sulfanilic acid - Risk and Safety
| Risk Codes | R36/38 - Irritating to eyes and skin. R43 - May cause sensitization by skin contact R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S37 - Wear suitable gloves. S24 - Avoid contact with skin. S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2790 8/PG 3 |
| WGK Germany | 1 |
| RTECS | WP3895500 |
| TSCA | Yes |
| HS Code | 29214210 |
| Toxicity | LD50 orally in Rabbit: 12300 mg/kg |
Sulfanilic acid - Upstream Downstream Industry
| Raw Materials | Aniline Sulfuric acid |
| Downstream Products | Methyl Orange |
Sulfanilic acid - Nature
Open Data Verified Data
white, off-white crystals or powder. mp is about 288 ° C. (decomposition); Relative density d251. 485. Soluble in ammonia and alkali metal hydroxide or carbonate solution, more soluble in hot water, slightly soluble in cold water, slightly soluble in hot methanol, almost insoluble in ethanol, ether, benzene. Water
The solubility is:(20 °c) 1%;(30 °c) 1.45%;(40 °c) 1.94%. Photochromic. The decomposition and carbonization were started at 280 °c. It is acidic and irritating. Thermal decomposition, release of nitrogen, sulfur oxides and other toxic gases.
Last Update：2025-06-10 22:55:16
Sulfanilic acid - Preparation Method
Open Data Verified Data
aniline was reacted Dropwise into concentrated sulfuric acid, and the reaction mixture was poured into cold water to obtain a colorless precipitate of p-aminobenzenesulfonic acid. After cooling, filtration and drying gave p-aminobenzenesulfonic acid.
Last Update：2025-06-10 22:55:16
Sulfanilic acid - Application
Open Data Verified Data
Reference Reagent. Determination of aluminum, magnesium, potassium, sodium, iodine, iodide and nitrite. The nitrite was determined with 1-Naphthylamine, and osmium and ruthenium were examined. Potassium can be determined indirectly by potassium nitrite. Determination of serum bilirubin, soil analysis. It is also used in the manufacture of printing and dyeing auxiliaries, pesticides, fungicides, spices, food pigments, pharmaceutical building materials and other fields.
Last Update：2025-08-19 16:24:40
Sulfanilic acid - Safety
Open Data Verified Data
mouse oral LD50:>3200mg/kg. Harmful to the body after ingestion, inhalation or absorption through the skin. Has a stimulating effect. Keep away from fire and heat source. It should be stored separately from oxidants, acids and alkalis, and mixed storage should be avoided. Store in a cool, ventilated warehouse. Keep away from fire and heat source.
Last Update：2022-01-01 09:25:29
Sulfanilic acid - Reference Information
| LogP | -2.3 at 25℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Uses | Used for manufacturing azo dyes, etc., and also used as pesticides for preventing and controlling wheat rust Mainly used for manufacturing dyes, printing and dyeing auxiliaries and preventing wheat rust And used as intermediates such as spices, food pigments, medicines, whitening agents, pesticides, etc. used in organic synthesis, also used as chromatography reagent, etc. used as reference reagent, experimental reagent and chromatography reagent Sulfanilic acid is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich holmium reagent, for detecting of nitrites. Antibacterial. verification of ammonia, cerium, and nitrite, determination of aluminum, magnesium, potassium, sodium, iodine, iodide and nitrite. The elemental analysis standards of carbon, hydrogen, nitrogen, oxygen and sulfur are used together with 1-naphthylamine to determine nitrite, test osmium and ruthenium, and indirectly determine potassium through potassium nitrite, determine serum bilirubin, and analyze soil. |
| Production method | It is obtained by reacting aniline with sulfuric acid to form a salt and then translocation. |
| category | pesticide |
| toxicity classification | low toxicity |
| acute toxicity | oral-rat LD50: 12300 mg/kg |
| stimulation data | skin-rabbit 500 mg/24 hours mild; Eye-rabbit 100 mg/24 hours moderate |
| flammability hazard characteristics | Combustion produces toxic nitrogen oxides and sulfur oxide gases |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
| fire extinguishing agent | dry powder, foam, sand |
| spontaneous combustion temperature | >400°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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View History
Sulfanilic acid
1004-17-7
605-71-0
1189-09-9
2305-05-7
ammoniumhydrogenbifluoride
Lorcaserin A
84512-08-3
25513-64-8
41126-15-2
1004-17-7
605-71-0
1189-09-9
2305-05-7
ammoniumhydrogenbifluoride
Lorcaserin A
84512-08-3
25513-64-8
41126-15-2
Raw Materials for Sulfanilic acid
Downstream Products for Sulfanilic acid